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Yevgeniya Lekomtseva

Yevgeniya Lekomtseva

AUFF-Ukraine research fellow, Aarhus Institute of Advanced Studies, Denmark and previously State Institute of Neurology, Psychiatry and Narcology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine

 

 

Research project

Epilepsy affects approximately 1–2% of the general population and there are gender differences in the expression of the disease and the impact on health. Catamenial Epilepsy (CE) is a condition in which seizures, either the frequency or severity of seizures, are increased or occur during a certain phase of the ovarian cycle (OC). CE is seen in almost 40% of women with epilepsy, and it is a very important medical problem. Catamenial seizures are influenced by the cyclical sex steroid hormone changes during OC where estrogen is thought to be proconvulsive, increasing epileptiform discharges and seizure frequency; whilst progesterone is thought to be anticonvulsive, reducing epileptiform discharges and clinical seizure occurrence. In addition to seizure clustering in relation to sex hormones, a relationship with circadian rhythms is also recognized. Epileptic seizures do not often strike randomly, but may occur in circadian patterns. The daily periodicity of seizures suggests a direct circadian influence on seizures of limbic origin where melatonin modulates circadian biorhythms and depresses brain excitability, prevents seizures and reduces GABAergic function.

Short bio

Medical Doctor, 2000; Neurology, 2002; PhD in Neurology, 2005; Psychiatry, 2019; Clinical Fellowships, AAF (2011, 2013, 2018). Research interests: epilepsy and paroxysmal states, catamenial epilepsy, circadian rhythms, melatonin, post-injury period following traumatic brain injury, lactate, the oxidative status, autoantibodies to VGPCs, GAD, axonal degeneration, tau protein, neuroinflammation, proinflammatory interleukins

Collaborating department at Aarhus University during the fellowship

The Department of Clinical Medicine, Faculty of Health, Aarhus University

Area of research:

Medical Sciences

Fellowship period:

7 June 2022 - 6 June 2022

Contact:

au724295@uni.au.dk