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Tomonori Takeuchi


Current position: Team Leader, DANDRITE and associate professor, Department of Biomedicine, Aarhus University, Denmark

During his AIAS-COFUND fellowship Associate Professor Tomonori Takeuchi worked on the project 'Enhancing everyday memory with novelty'.

Project at AIAS

Most of our everyday memories are forgotten. However, the retention of these trivial memories is enhanced when something novel/salient happens shortly before or after the time of memory encoding. Dopamine signaling in the hippocampus plays an important role in this novelty-associated memory enhancement. We recently made a ground-breaking finding (Takeuchi et al., Nature, 2016): projections from the noradrenergic locus coeruleus to the hippocampus can drive the novelty-induced memory enhancement via non-canonical release of dopamine. This is a completely new concept that I will explore by uncovering the molecular mechanisms of novelty detection and subsequent dopamine-dependent memory modulation.  

I would like to address two issues: 

(1) Which brain area detects novelty and how its signal reaches the locus coeruleus?

(2) Which proteins play crucial roles in novelty-induced memory enhancement in the hippocampus? 

I will use sophisticated and well-defined everyday memory tasks in rats, designed to mimic the typical memory of daily life in humans, combined with a multidisciplinary approach. Identification of proteins that enhance memory retention will have the potential to reveal new drug targets for treatment/restoration of lost memory function.

Project title:

Enhancing everyday memory with novelty

Area of research:


Fellowship period:

1 Feb 2018 – 31 Jul 2019

Fellowship type

AIAS-COFUND Marie Skłodowska-Curie fellow

This fellowship has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under the Marie Skłodowska-Curie grant agreement No 609033 and The Aarhus University Research Foundation.