The focus of my research is tumor biology and the molecular mechanism in tumor progression. In my group we have established in vivo tumor models in mice and mini pigs, with the use of CRIPRS technology. Hereby, disease models can be generated rapidly with genetic alterations. The model can target different organs and multiple candidate genes simultaneously and therefore specific biological questions can be addressed in an in vivo setting. Currently, two projects are ongoing in these models, one focusing on lung cancer and one related to metastatic prostate cancer.
Martin K. Thomsen has a profound interest in cancer biology and use of in vivo models to explore biological questions. He obtained his PhD at The Institute of Cancer Research in London working on prostate cancer. Hereafter he trained at the Spanish National Cancer Research Centre in Madrid, working with genetically modified mouse models and patient samples to study liver diseases.
In 2016 Martin K. Thomsen started his research group at the Institute for Clinical Medicine at Aarhus University, Denmark. The aim of the group is to study cancer in advanced animal models by use of CRISPR technology. For this, a Cas9 mini pig has been cloned and a similar mouse model has been obtained. Projects related to lung, skin and prostate cancer are currently ongoing.
In vivo cancer models based on CRISPR/Cas9
Area of research:
01 Feb 2019 – 31 Jan 2020
Photo: Whole prostate