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Jens Georg Leipziger


Current position: Professor, Department of Biomedicine, Aarhus University

During his Jens Christian Skou Fellowship, Jens Georg Leipziger worked on the project 'The discovery, relevance and application of the Cystic Fibrosis Urine Test'

Project at AIAS

Cystic fibrosis (CF) is the most common lethal genetic disease in Caucasians with a frequency of ~1 in 2000 new-borns caused by loss of function of the Cystic Fibrosis Transmembrane Regulator gene (CFTR). CFTR is a Cl- channel localized in the apical membrane of glandular tissues like the gastrointestinal tract and the lungs. We have identified the molecular mechanism of CFTR-dependent urine bicarbonate excretion in the collecting duct. CFTR knock-out mice cannot respond to increase their urine bicarbonate excretion following a defined acute oral load. We find a similar phenotype in human CF patients. We have invented a CF urine test that is simple and quantifies the ability to excrete bicarbonate with the urine. This test has solid potential to characterize the degree of functional loss in CF patients. It will allow quantification of drug therapy success and will identify drug non-responders.

Project title:

The discovery, relevance and application of the Cystic Fibrosis Urine Test    

Area of research:

Medicine, physiology, and nephrology    

Fellowship period:

1 Oct 2019 – 30 Sep 2020

Fellowship type:

Jens Christian Skou fellow

This fellowship has received funding from The Aarhus University Research Foundation.