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Yevgeniya Lekomtseva

Former AUFF-Ukraine research fellow, Aarhus Institute of Advanced Studies, Denmark, and previously State Institute of Neurology, Psychiatry and Narcology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine

Current position: M.D., Ph.D., and Ass. Prof. at State Institute of Neurology, Psychiatry and Narcology, NAMS of Ukraine, Ukraine

Research project

Epilepsy affects approximately 1–2% of the general population and there are gender differences in the expression of the disease and the impact on health. Catamenial Epilepsy (CE) is a condition in which seizures, either the frequency or severity of seizures, are increased or occur during a certain phase of the ovarian cycle (OC). CE is seen in almost 40% of women with epilepsy, and it is a very important medical problem. Catamenial seizures are influenced by the cyclical sex steroid hormone changes during OC where estrogen is thought to be proconvulsive, increasing epileptiform discharges and seizure frequency; whilst progesterone is thought to be anticonvulsive, reducing epileptiform discharges and clinical seizure occurrence. In addition to seizure clustering in relation to sex hormones, a relationship with circadian rhythms is also recognized. Epileptic seizures do not often strike randomly, but may occur in circadian patterns. The daily periodicity of seizures suggests a direct circadian influence on seizures of limbic origin where melatonin modulates circadian biorhythms and depresses brain excitability, prevents seizures and reduces GABAergic function.

Collaborating department at Aarhus University during the fellowship

The Department of Clinical Medicine, Faculty of Health, Aarhus University

Area of research:

Medical Sciences

Fellowship period:

4 June 2022 - 3 June 2023

Fellowship type: 

AUFF-Ukraine fellow

This fellowship has received funding from The Aarhus University Research Foundation (AUFF)