Aarhus University Seal / Aarhus Universitets segl

AIAS Seminar: Christian Kanstrup Holm

Multiple sclerosis medicine inhibits coronavirus replication

2020.07.07 | AIAS

Date Mon 19 Oct
Time 14:15 15:30
Location Virtual via Zoom

The talk is streamed via Zoom. Join URL: https://aarhusuniversity.zoom.us/j/65832051031 to attend virtually. 


Speaker: Christian Kanstrup Holm, Department of Biomedicine, Aarhus University  

Abstract

Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here, we demonstrate that the NRF2 antioxidant gene expression pathway is suppressed in biopsies obtained from COVID-19 patients. Further, we uncover that NRF2 agonists 4-octyl-itaconate (4-OI) and the clinically approved dimethyl fumarate (DMF) induce a cellular antiviral program that potently inhibits replication of SARS-CoV2 across cell lines. The inhibitory effect of 4-OI and DMF extends to the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism. In addition, 4-OI and DMF limit host inflammatory responses to SARS-CoV2 infection associated with airway COVID-19 pathology. In conclusion, NRF2 agonists 4-OI and DMF induce a distinct IFN-independent antiviral program that is broadly effective in limiting virus replication and in suppressing the pro-inflammatory responses of human pathogenic viruses, including SARS-CoV2.    

Short bio

See Christian Kanstrup Holm's profile at Aarhus University

What is an AIAS Seminar?

The AIAS Seminar is a session of seminars held by the AIAS fellow or by other speakers proposed by the fellows. In each seminar, one fellow will present and discuss his/her current research and research project, closing off with a question and discussion session.

All seminars are held in English.

import_18:Seminar