The seminar will focus on the viability of using the vitamin B12 dietary pathway for drug delivery and targeting. In particular, the seminar will focus on oral, sub-cutaneous and i.v administration of B12 conjugates of the anorectic peptide PYY3-36 and the incretin peptide Exendin-4.

Results demonstrate that the pathway is highly limited in several aspects including oral uptake capacity and general pharmacokinetic parameter improvements for example, but does demonstrate protective effects for peptides against gastric and serum protease degradation, improves blood brain barrier passage and offers scope for cellular targeting. The most recent results of Doyle’s group will be described in addition to thoughts of where a successful B12 based ´drug´ may be obtained and future insights to the topic.

Duration: 40 min lecture followed by a discussion.

About the speaker

Dr. Robert P. Doyle
Professor of Chemistry
Associate Professor of Medicine (adjunct)
SUNY, Upstate Medical University Syracuse, New York, USA rpdoyle@syr.edu

Read more at: http://asfaculty.syr.edu/pages/chem/Doyle-Robert.html

Participation

The seminar is open to all interested in the topic and registration is not necessary. Coffee and tea will be served.

Organiser and contact

Prof. Rima Obeid
Aarhus Institute for Advanced Studies (AIAS), Aarhus University
Phone: + 45 8715 3652
Cell phone: +45 501 25 875
rimaobeid@aias.au.dk