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AIAS Guest lecture: Prof. Jonathan Strefford, Cancer Molecular Genetics within Medicine, University of Southhampton, UK

Dissecting the Cancer Genome; the example of CLL and associated disorders

2016.04.14 | AIAS

Date Fri 17 Jun
Time 13:30 15:00
Location The AIAS Auditorium, Building 1632, Høegh-Guldbergs Gade 6B, 8000 Aarhus C

Abstract

Mature B-cell malignancies, such as chronic lymphocytic leukemia remains at the forefront of the genetic analysis of human tumours, principally due its prevalence, protracted natural history and accessibility to suitable material for analysis. With the application of high-throughput genetic technologies, we have an unbridled view of the architecture of the genome of these conditions, including a comprehensive description of the copy number and mutational landscape of the disease, a detailed picture of clonal evolution during pathogenesis, and the molecular mechanisms that drive genomic instability and therapeutic resistance. This work has nuanced the prognostic importance of established copy number alterations, and identified novel prognostically relevant gene mutations that function within biological pathways that are attractive treatment targets. This lecture will cover our currently thinking on the clinical and biological importance of genomic lesions in CLL and associated disorders, such as splenic marginal zone lymphoma. This will include the identification of novel genomic lesions, their possible pathogenic role in these diseases, and how this knowledge could be exploited to benefit patient care. 

More about the speaker

http://www.southampton.ac.uk/medicine/about/staff/jcs.page

 

Participation

All are welcome and registration is not necessary - just show up. After the lecture, further discussion is possible accompanied by coffee, tea and cake in the AIAS Hall.

Organiser and contact

The guest lecture is organised as a collaboration between Tomasz K. Wojdacz (AIAS) and Lise Lotte Hansen (Aarhus University):

Tomasz K. Wojdacz, AIAS Fellow
Aarhus Institute for Advanced Studies (AIAS), Aarhus University
wojdacz@biomed.au.dk
Phone: +4587152136

Lise Lotte Hansen, Associate Professor
Department of Biomedicine, Aarhus University
lotte@biomed.au.dk
Phone: +4587167776 

 

 

Lecture / talk